Brand + Infernal Conduit

Brand's passive triggers it — first ability hit procs Magic Missile twice.

Once you grab Vulnerable, use it so item DoTs (Liandry's, Rylai's, etc.) and abilities crit. Add Jeweled Gauntlet's 45% crit chance for 70% total — DoTs become real damage. Shadowflame doubles up the crit. Once Vulnerable lands, go double-DoT: Shadowflame + Vulnerable doubles up crit damage on abilities.

Void Rift as core, paired with Dice Master for flat magic pen forge. Brand's passive also counts as ability cast — he can proc Void Rift with one ability hit, paired with huge AoE for screen-wide Rifts. Dice Master + flat magic pen forge for damage.

Centered on Infernal Conduit — burn applies CDR continuously. In 5v5 Mayhem, burning multiple enemies = effectively infinite cast. With Infernal Conduit + sustained-damage items, you spam abilities nonstop.