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Pantheon + Vulnerability
S Tier Combo
Mandatory: Vulnerable + Executioner. With Bork, jump anyone — they die; no front-line concept, squishies vaporized. Hexes must have Vulnerable + Executioner; flex rest. Back to Basics and Clown College are huge prismatic upgrades; gold Upgrade Infinity Edge / Vampirism / Transmute Chaos / Soul Siphon all great; silver Adapt / Upgrade Collector / Big Hits / Brute Force / Bloodlust are also solid. Items: Hubris start, then Bork, then Death's Dance, pick from Liandry's / Black Cleaver / Eclipse / Bloodthirster.
Submitted by ARAMMayhem.com
About Pantheon
About Vulnerability
Vulnerability
gold 54.39% WR
All Pantheon combos
View all Pantheon combos → 5 combos
More Vulnerability Combos
Lucian S Ult benefits from Vulnerability. Insane damage. 
Katarina S R procs Vulnerability. 
Rumble S Vulnerability + Shadowflame creates an 8x multiplicative damage amp with Prismatic. Katarina S Katarina's ult counts as a high-frequency channeled DPS ability and triggers on-hit. Pair with Kraken Slayer, Bloodthirster/Bork, and Jeweled Gauntlet + Vulnerable for the highest single-second DPS in the game. Every dagger thrown during her spin triggers a 7.17x damage multiplier. 
Brand S Once you grab Vulnerable, use it so item DoTs (Liandry's, Rylai's, etc.) and abilities crit. Add Jeweled Gauntlet's 45% crit chance for 70% total — DoTs become real damage. Shadowflame doubles up the crit. Once Vulnerable lands, go double-DoT: Shadowflame + Vulnerable doubles up crit damage on abilities. 
Syndra S Forge: max crit damage to cap. Rumble S Rumble's Q and R are extremely high-frequency DoTs. With Jeweled Gauntlet + Vulnerable + Infinity Edge + Shadowflame, each burn tick gets amplified 7.17x — annihilates even tanks. As an AP champion, Jeweled Gauntlet's AP-to-crit ratio is excellent — late, you hit full crit without crit items. 
Mel S Q's multi-hits all benefit from Vulnerable's amp — damage is absurd. Keep exploring
Pantheon + Vulnerability ARAM: Mayhem Combo Guide
This S-tier combo pairs Pantheon with Vulnerability in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Mandatory: Vulnerable + Executioner. With Bork, jump anyone — they die; no front-line concept, squishies vaporized. Hexes must have Vulnerable + Executioner; flex rest. Back to Basics and Clown College are huge prismatic upgrades; gold Upgrade Infinity Edge / Vampirism / Transmute Chaos / Soul Siphon all great; silver Adapt / Upgrade Collector / Big Hits / Brute Force / Bloodlust are also solid. Items: Hubris start, then Bork, then Death's Dance, pick from Liandry's / Black Cleaver / Eclipse / Bloodthirster.