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TryndamereS+ Tier ComboCircle of Death converts heal into magic damage; Trynd Q has huge AP scaling — late Q hits 3000+ damage, deletes squishies. Stack AP and magic pen. Forge: AP > magic pen > MS. Stack fury before Q'ing; CoD has 1000 range, get close.
YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.
YoneS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s. Yone's Q counts as an auto, so at 1.33s Q cooldown you get infinite Q — pair with Ruined King for permanent shield uptime.
AatroxS Tier ComboJeweled Gauntlet bloodlust build. Don't play without first-hex Jeweled Gauntlet — tanky and damaging.AatroxS Tier ComboWith ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely.
BriarS Tier ComboCrit build deals huge damage — lifesteal heals you to full through Grievous Wounds in two bites.
DianaS Tier ComboTank Diana with W shield. Have fun with that.
HecarimS Tier ComboCrit chance + Death's Dance — abilities grant shields based on crit, while Death's Dance converts 30% damage into bleed that the shields absorb. Keep ability frequency high and you maintain a permanent 30% damage reduction.
+Infinite missiles. Tech gun + crit = bloodlust build.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · C
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Kai'Sa
About Critical Healing
Critical Healing
gold49.74% WR
Your heals and shields now have a chance equal to your critical strike chance to increase in effectiveness by 40%. Additionally, gain 25% critical strike chance.
View full augment page →All Kai'Sa combos
View all Kai'Sa combos →4 combos
More Critical Healing Combos
TryndamereS+ Tier ComboCircle of Death converts heal into magic damage; Trynd Q has huge AP scaling — late Q hits 3000+ damage, deletes squishies. Stack AP and magic pen. Forge: AP > magic pen > MS. Stack fury before Q'ing; CoD has 1000 range, get close.YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.YoneS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s. Yone's Q counts as an auto, so at 1.33s Q cooldown you get infinite Q — pair with Ruined King for permanent shield uptime.AatroxS Tier ComboJeweled Gauntlet bloodlust build. Don't play without first-hex Jeweled Gauntlet — tanky and damaging.AatroxS Tier ComboWith ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely.BriarS Tier ComboCrit build deals huge damage — lifesteal heals you to full through Grievous Wounds in two bites.DianaS Tier ComboTank Diana with W shield. Have fun with that.HecarimS Tier ComboCrit chance + Death's Dance — abilities grant shields based on crit, while Death's Dance converts 30% damage into bleed that the shields absorb. Keep ability frequency high and you maintain a permanent 30% damage reduction.Keep exploring
Critical Healing + Critical Missile Kai'Sa Combo
This S-tier combo pairs Kai'Sa with Critical Healing in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Infinite missiles. Tech gun + crit = bloodlust build.