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Kai'Sa + Mystic Punch
S Tier Combo
Use new Mystic Punch's all-ability CDR with Runaan's split shots (also procs the hex), plus Dusk and Dawn double-proc — one auto reduces all CDs by 5s, enabling infinite Icathian Rain. Core is Mystic Punch + Runaan's combo; you have to actually hit.
Submitted by ARAMMayhem.com
About Kai'Sa
About Mystic Punch
Mystic Punch
prismatic 53.75% WR
All Kai'Sa combos
View all Kai'Sa combos → 4 combos
More Mystic Punch Combos
Bel'Veth S Q hit directly resets W and E. 
Master Yi S Pick this and enjoy. Q applies on-hit effects and every tick triggers Mystic Punch. 
Volibear S Mystic Punch slashes ability cooldowns hard — pair with Navori Quickblades for effective infinite cast. 
Katarina S Katarina's R procs on-hits, so Mystic Punch slashes her cooldowns mid-spin, enabling near-perpetual ult reaping. 
Irelia S Around 300 ability haste plus Mystic Punch enables infinite Q. 
Lucian S Lucian gets two autos per cast — Mystic Punch + Navori Quickblades + some CDR enables seamless EA kiting. 
Yone S Slow and Steady converts attack speed to AD without reducing Q's cooldown — Q's tooltip damage is already huge. 
Zed S Ethereal Weapon makes abilities trigger item effects — feels like old-school Zed. Keep exploring
Kai'Sa + Mystic Punch ARAM: Mayhem Combo Guide
This S-tier combo pairs Kai'Sa with Mystic Punch in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Use new Mystic Punch's all-ability CDR with Runaan's split shots (also procs the hex), plus Dusk and Dawn double-proc — one auto reduces all CDs by 5s, enabling infinite Icathian Rain. Core is Mystic Punch + Runaan's combo; you have to actually hit.