← Back to Combos
+
FioraS+ Tier ComboMystic Punch slashes Q's cooldown, opening up Blade Waltz freely. With Slow and Steady you keep E up full uptime + spam Q, soaking up all that converted AD. New Mystic Punch also reduces R — three R's per fight.
HecarimS+ Tier ComboClassic Ethereal Weapon + Mystic Punch combo — abilities trigger on-hit effects to refresh CDs. Hard to assemble — requires both specific hexes; Mystic Punch alone isn't worth it.
JaxS+ Tier ComboMystic Punch + Dusk and Dawn slashes CDs — keep E up full uptime for permanent block.
Master YiS+ Tier ComboMystic Punch + huge ability haste makes Q effectively zero-CD — infinite Q untargetable + dodging every attack. Threshold is usually 190 haste plus Mystic Punch; absolutely grab Essence Reaver or mana runs out fast.
YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.
YoneS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s. Yone's Q counts as an auto, so at 1.33s Q cooldown you get infinite Q — pair with Ruined King for permanent shield uptime.
Bel'VethS Tier ComboQ hit directly resets W and E.Bel'VethS Tier ComboBel'Veth's Q and W are AoE — multi-hits cut multiple CDs, making QWE basically zero-CD. Infinite QW knockup.
+Use new Mystic Punch's all-ability CDR with Runaan's split shots (also procs the hex), plus Dusk and Dawn double-proc — one auto reduces all CDs by 5s, enabling infinite Icathian Rain. Core is Mystic Punch + Runaan's combo; you have to actually hit.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · C
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Kai'Sa
About Mystic Punch
Mystic Punch
prismatic56.24% WR
Basic attacks on-hit reduce the cooldowns of your abilities by 1.25 seconds.
View full augment page →All Kai'Sa combos
View all Kai'Sa combos →4 combos
More Mystic Punch Combos
FioraS+ Tier ComboMystic Punch slashes Q's cooldown, opening up Blade Waltz freely. With Slow and Steady you keep E up full uptime + spam Q, soaking up all that converted AD. New Mystic Punch also reduces R — three R's per fight.HecarimS+ Tier ComboClassic Ethereal Weapon + Mystic Punch combo — abilities trigger on-hit effects to refresh CDs. Hard to assemble — requires both specific hexes; Mystic Punch alone isn't worth it.JaxS+ Tier ComboMystic Punch + Dusk and Dawn slashes CDs — keep E up full uptime for permanent block.Master YiS+ Tier ComboMystic Punch + huge ability haste makes Q effectively zero-CD — infinite Q untargetable + dodging every attack. Threshold is usually 190 haste plus Mystic Punch; absolutely grab Essence Reaver or mana runs out fast.YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.YoneS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s. Yone's Q counts as an auto, so at 1.33s Q cooldown you get infinite Q — pair with Ruined King for permanent shield uptime.Bel'VethS Tier ComboQ hit directly resets W and E.Bel'VethS Tier ComboBel'Veth's Q and W are AoE — multi-hits cut multiple CDs, making QWE basically zero-CD. Infinite QW knockup.Keep exploring
Mystic Punch Kai'Sa Combo
This S-tier combo pairs Kai'Sa with Mystic Punch in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Use new Mystic Punch's all-ability CDR with Runaan's split shots (also procs the hex), plus Dusk and Dawn double-proc — one auto reduces all CDs by 5s, enabling infinite Icathian Rain. Core is Mystic Punch + Runaan's combo; you have to actually hit.