Eureka is another excellent Karthus spike, giving him frequent ult pressure and strong snowball tempo.
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About Eureka
More Karthus Combos
Clown College S Turn on E, then use Clown College to walk in and burn them. The fear box after death traps people in your E. 
Ultimate Revolution S Ultimate Revolution makes Karthus game-warping with near-constant double-ult windows. 
Infinite Recursion S Infinite Recursion lets Karthus cycle Requiem absurdly fast and constantly pressure team HP bars. More Eureka Combos
Karthus + Eureka ARAM: Mayhem Combo Guide
This A-tier combo pairs Karthus with Eureka in ARAM: Mayhem. A solid choice that works well in most games.
Eureka is another excellent Karthus spike, giving him frequent ult pressure and strong snowball tempo.