+ 
Mel + Vulnerability
S Tier Combo
Q's multi-hits all benefit from Vulnerable's amp — damage is absurd.
Submitted by ARAMMayhem.com
About Mel
About Vulnerability
Vulnerability
gold 54.39% WR
All Mel combos
View all Mel combos → 4 combos
More Vulnerability Combos
Lucian S Ult benefits from Vulnerability. Insane damage. 
Katarina S R procs Vulnerability. 
Rumble S Vulnerability + Shadowflame creates an 8x multiplicative damage amp with Prismatic. Katarina S Katarina's ult counts as a high-frequency channeled DPS ability and triggers on-hit. Pair with Kraken Slayer, Bloodthirster/Bork, and Jeweled Gauntlet + Vulnerable for the highest single-second DPS in the game. Every dagger thrown during her spin triggers a 7.17x damage multiplier. 
Brand S Once you grab Vulnerable, use it so item DoTs (Liandry's, Rylai's, etc.) and abilities crit. Add Jeweled Gauntlet's 45% crit chance for 70% total — DoTs become real damage. Shadowflame doubles up the crit. Once Vulnerable lands, go double-DoT: Shadowflame + Vulnerable doubles up crit damage on abilities. 
Syndra S Forge: max crit damage to cap. Rumble S Rumble's Q and R are extremely high-frequency DoTs. With Jeweled Gauntlet + Vulnerable + Infinity Edge + Shadowflame, each burn tick gets amplified 7.17x — annihilates even tanks. As an AP champion, Jeweled Gauntlet's AP-to-crit ratio is excellent — late, you hit full crit without crit items. 
Naafiri S Q1 has a bleed — Ethereal Weapon procs the whole bleed window. Wolf pack charges in and one-shots. Keep exploring
Mel + Vulnerability ARAM: Mayhem Combo Guide
This S-tier combo pairs Mel with Vulnerability in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Q's multi-hits all benefit from Vulnerable's amp — damage is absurd.