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AmumuS Tier ComboStack Triple-Stack Dragon. Forge: take omnivamp.
AzirS Tier ComboMagic.
Bel'VethS Tier ComboPassive stacks benefit from Shrink Engine — late-game attack speed easily exceeds 6.0.
KayleS Tier ComboKayle's ascended passive bonus fire makes autos count as two hits, so Master of Duality stacks both AD and AP at once. W heals scale massively with AP, and Kayle scales into a god — half-tank for survival. Survive long enough to ramp, then take over.
NasusS Tier ComboStack Shrink Engine synergies — Nasus already gets bonus per stack; on a TF Mobi Q stacks 24 normally, 36 with two, 48 with three, 72 with four Shrink Engines.SennaS Tier ComboNew Statikk Shiv's multi-procs. Weak early — pick stat-boosting hexes.
TryndamereS Tier ComboTrynd's Q has huge AP scaling (1.2x) plus heal scaling; Master of Duality's AP enables full-HP heals. Navori cuts Q CD — extreme survivability. Weave autos and abilities to constantly proc heals and keep MoD stacks up.
UrgotS Tier ComboSpeed run build. 1.
+As a ranged champ with Runaan's split shots, one auto stacks 3 layers of Master of Duality. High AP means Q damage and ally heals become absurd — you're a mobile fountain. Build Runaan's first to ramp stacks fast, then leverage range for stacking from safety.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · B
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Senna
About Master of Duality
Master of Duality
prismatic50.15% WR
Basic attacks on-hit grant 6 to 18 ability power and damaging abilities once per cast instance grant 3 to 9 bonus attack damage, lasting for 5 seconds, with the duration of both refreshing on subsequent hits, and stacking infinitely.
View full augment page →All Senna combos
View all Senna combos →7 combos
More Master of Duality Combos
AmumuS Tier ComboStack Triple-Stack Dragon. Forge: take omnivamp.AzirS Tier ComboMagic.Bel'VethS Tier ComboPassive stacks benefit from Shrink Engine — late-game attack speed easily exceeds 6.0.KayleS Tier ComboKayle's ascended passive bonus fire makes autos count as two hits, so Master of Duality stacks both AD and AP at once. W heals scale massively with AP, and Kayle scales into a god — half-tank for survival. Survive long enough to ramp, then take over.NasusS Tier ComboStack Shrink Engine synergies — Nasus already gets bonus per stack; on a TF Mobi Q stacks 24 normally, 36 with two, 48 with three, 72 with four Shrink Engines.SennaS Tier ComboNew Statikk Shiv's multi-procs. Weak early — pick stat-boosting hexes.TryndamereS Tier ComboTrynd's Q has huge AP scaling (1.2x) plus heal scaling; Master of Duality's AP enables full-HP heals. Navori cuts Q CD — extreme survivability. Weave autos and abilities to constantly proc heals and keep MoD stacks up.UrgotS Tier ComboSpeed run build. 1.Keep exploring
Master of Duality Senna Combo
This S-tier combo pairs Senna with Master of Duality in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
As a ranged champ with Runaan's split shots, one auto stacks 3 layers of Master of Duality. High AP means Q damage and ally heals become absurd — you're a mobile fountain. Build Runaan's first to ramp stacks fast, then leverage range for stacking from safety.