+ 
Twitch + Magic Missile
A Tier Combo
AP build amps Twitch's passive true damage and E burst; W's huge slow locks enemies down. Slows don't stack — no Rylai's. Twitch's passive can't proc Liandry's or Ethereal Weapon — don't pick those.
Submitted by ARAMMayhem.com
About Twitch
About Magic Missile
Magic Missile
gold 60.73% WR
All Twitch combos
View all Twitch combos → 5 combos
More Magic Missile Combos
Brand S Brand's passive triggers it — first ability hit procs Magic Missile twice. 
Azir S Each W soldier stab and passive tower shot procs Magic Missile. 
Kayle S Passive flame waves trigger Magic Missile. After level 16, you melt tanks. 
Lux S Ethereal Weapon procs Lux's passive — E into multiple enemies and you can detonate the passive mark on all of them. Lux S Pure AP is squishy and damage-light — go half-tank and stack CDR for faster passive procs. Use R to clear waves. Brand S Once you grab Vulnerable, use it so item DoTs (Liandry's, Rylai's, etc.) and abilities crit. Add Jeweled Gauntlet's 45% crit chance for 70% total — DoTs become real damage. Shadowflame doubles up the crit. Once Vulnerable lands, go double-DoT: Shadowflame + Vulnerable doubles up crit damage on abilities. 
Syndra S Forge: max crit damage to cap. 
Shyvana S Ultimate Awakening gives small abilities 300 haste — Shyvana spams E at extreme frequency. Keep exploring
Twitch + Magic Missile ARAM: Mayhem Combo Guide
This A-tier combo pairs Twitch with Magic Missile in ARAM: Mayhem. A solid choice that works well in most games.
AP build amps Twitch's passive true damage and E burst; W's huge slow locks enemies down. Slows don't stack — no Rylai's. Twitch's passive can't proc Liandry's or Ethereal Weapon — don't pick those.