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Cassiopeia + Cruelty
S Tier Combo
Cass W ground triggers Cruelty over a large sustained area — even enemies who walk in late retrigger it. R petrify enables huge burst. W+R combo dumps multiple Cruelty procs for cleanup.
Submitted by ARAMMayhem.com
About Cassiopeia
About Cruelty
Cruelty
prismatic 51.01% WR
More Cruelty Combos
Rell S Rell has tons of AoE CC and grouping. One CC instance hits multiple Cruelty procs on a single target. 
Renata Glasc S Q triggers multiple Cruelty procs. Ult does too. 
Syndra S Pairs with E for massive AoE CC into double Cruelty proc. Truly disgusting. 
Neeko S Ult lifts enemies up for a guaranteed Cruelty proc. 
Nami S Q and R both proc Cruelty multiple times with their AoE. 
Rakan S Pull enemies in with R, then lift with W for double Comet procs in a small radius — huge damage. 
Hwei S Every Hwei E procs Cruelty — EE especially pulls enemies into one spot. Since Cruelty is AoE, grouped enemies eat stacked Comet damage. After EE pulls them in, the more bodies, the more terrifying the damage. 
Seraphine S Build Rylai's so E becomes AoE hard CC, which procs Cruelty. Keep exploring
Cassiopeia + Cruelty ARAM: Mayhem Combo Guide
This S-tier combo pairs Cassiopeia with Cruelty in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Cass W ground triggers Cruelty over a large sustained area — even enemies who walk in late retrigger it. R petrify enables huge burst. W+R combo dumps multiple Cruelty procs for cleanup.