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Karma + Jeweled Gauntlet
S Tier Combo
Play this when the enemy lineup is squishy. RQ for explosive damage.
Submitted by ARAMMayhem.com
About Karma
About Jeweled Gauntlet
Jeweled Gauntlet
prismatic 59.14% WR
If both Jeweled Gauntlet and Vulnerability are equipped, only rolls the critical strike chance of the augment that has the higher critical damage (or either if equal).
More Jeweled Gauntlet Combos
Smolder S Q itself doesn't crit, but crit chance gives a percent damage bonus. With Jeweled Gauntlet, damage goes through the roof. 
Viego S Q and R can't crit normally, but crit chance gives percent bonus damage. With Jeweled Gauntlet, damage is absurd. 
Corki S All abilities can crit. Damage is nuts. 
Lucian S Stacks with Vulnerability. Ult touches someone and they're dead. 
Sett S Essential for lethality ult Sett. Enemy tanks become your strongest weapon. 
Udyr S Q and R proc it. 
Katarina S Katarina's ult counts as a high-frequency channeled DPS ability and triggers on-hit. Pair with Kraken Slayer, Bloodthirster/Bork, and Jeweled Gauntlet + Vulnerable for the highest single-second DPS in the game. Every dagger thrown during her spin triggers a 7.17x damage multiplier. 
Lux S Ethereal Weapon procs Lux's passive — E into multiple enemies and you can detonate the passive mark on all of them. Keep exploring
Karma + Jeweled Gauntlet ARAM: Mayhem Combo Guide
This S-tier combo pairs Karma with Jeweled Gauntlet in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Play this when the enemy lineup is squishy. RQ for explosive damage.