卡爾瑟斯+玻璃大砲SGlass Cannon is core to the suicide Karthus build. Main-E is more reliable AoE than Q, and Liandry's + Liandry's burn benefits from the Glass Cannon amp. Karthus already trades HP to position, so the % HP cost matters little; maximize damage before death.
卡爾瑟斯+因心成體SW reduces R's CD via Archmage's CDR refund. After casting R, spam W and Q to slash R's CD for full-map ults. R then W, spam Q during both cooldowns, recast W, repeat — about 16s per ult.
卡爾瑟斯+終極革新SUltimate Revolution bug is patched (no more 4 R's), but you still get one R per life — pair with the suicide build for monster output. This style doesn't need Plague's ult haste — build pure magic pen / AP for max R damage. Strongly recommend Final City Transit synergy.
卡爾瑟斯+小惡魔在低語SMax E, sub W — E burn drops fragments wildly; chase fragments, find enemies dead and you're at full HP.
卡爾瑟斯+虛空裂縫SOnce Void Rift is in hand, stack magic pen — damage explodes. Pop E snowball into the pile; main damage comes from Void Rift, so magic pen is priority. Liandry's can be skipped for Rabadon's.