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Ryze + Mad Scientist
S Tier Combo God Tier
Ascension combo (go big).
Submitted by ARAMMayhem.com
About Ryze
About Mad Scientist
Mad Scientist
prismatic 53.58% WR
All Ryze combos
View all Ryze combos → 22 combos · Page 1 of 3
More Mad Scientist Combos
Sion S Nobody can resist the joy of getting bigger. 
Trundle S R deals % magic damage — level 3 base is 30%, +16% at 800 AP, and 3500 AP hits 100% max HP. 
Shen S Shen's Q empowers his next 3 autos with % max-HP magic damage that scales with AP. Lvl 18 base is 4%; with Q's spirit blade hitting an enemy, it goes to 7% — three autos = 21% max HP. At 400 AP, three autos hit 45% max HP. Spirit-blade pull positioning is huge — hit-vs-miss roughly doubles damage. 
Mel S Q's multi-hits all benefit from Vulnerable's amp — damage is absurd. 
Renata Glasc S Renata's passive marks enemies; ally damage consumes the mark for % max-HP magic damage. At 600 AP, hits 14% max HP. Stack AP for damage and AS for marking frequency. Damage is attributed to Renata, so magic-pen forge works. 
Smolder S Q is AoE — each enemy hit reduces CD, so once Mystic Punch lands you have infinite Q. 
Sett S In Mayhem, Sett's W stores up to 35% max HP in grit. W damage scales with grit cap and AD, so stack HP and AD — late, you one-shot. Forge: AD > HP > MS. E pulls both sides together; if both sides have at least one unit (minions count), it stuns — wait for full grit, EW guaranteed. 
Pyke S Pyke passive converts 14 HP into 1 AD; Goliath gives 35% HP and 15% AD, so 8 HP = 1 AD — late, 1000+ AD easy. R scales with both AD and lethality — full-HP squishies are in execute range. Keep exploring
Ryze + Mad Scientist ARAM: Mayhem Combo Guide
This S-tier combo pairs Ryze with Mad Scientist in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Ascension combo (go big).