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FiddlesticksS+ Tier Combo[Hard to scale] Fiddle's Q deals % max-HP magic damage, doubled on feared targets. At 1467 AP, one fear+Q = 100% max HP. Forge: AD (with Adapt) > AP > magic pen. Hide in bush, one Q scares them dead.
FioraS+ Tier Combo[Hard to assemble] Heartsteel + Tank Engine stack infinite HP, Overlord's Bloodmail converts HP into AD. With Fiora's passive, around 2500 AD a single vital procs 100% max-HP true damage.
GragasS+ Tier ComboGragas W gives AP-scaling % damage reduction with a 2.5s invuln after channel. At 2050 AP, 100% reduction. But you have to spend the empowered auto before recasting W, so there's a downtime gap — not perma. Forge: AD (with Adapt) > AP > HP > resists.
MelS Tier ComboQ's multi-hits all benefit from Vulnerable's amp — damage is absurd.
PykeS Tier ComboPyke passive converts 14 HP into 1 AD; Goliath gives 35% HP and 15% AD, so 8 HP = 1 AD — late, 1000+ AD easy. R scales with both AD and lethality — full-HP squishies are in execute range.
Renata GlascS Tier ComboRenata's passive marks enemies; ally damage consumes the mark for % max-HP magic damage. At 600 AP, hits 14% max HP. Stack AP for damage and AS for marking frequency. Damage is attributed to Renata, so magic-pen forge works.RyzeS Tier Combo0.RyzeS Tier ComboSmug emperor — stack Heartsteel to bait enemies.
+Ascension combo (go big).
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · S
- From the site champion tier list.
- Champion tier context · Patch 26.20
- Updated Oct 12, 2026
About Ryze
About Mad Scientist
Mad Scientist
prismaticTier S
Upon acquiring this augment and each time you respawn, gain either 30% adaptive force, 20% bonus health, and 40% increased size or 70 ability haste, 40% bonus movement speed, and 40% reduced size.
View full augment page →All Ryze combos
View all Ryze combos →22 combos·Page 1 of 3
More Mad Scientist Combos
FiddlesticksS+ Tier Combo[Hard to scale] Fiddle's Q deals % max-HP magic damage, doubled on feared targets. At 1467 AP, one fear+Q = 100% max HP. Forge: AD (with Adapt) > AP > magic pen. Hide in bush, one Q scares them dead.FioraS+ Tier Combo[Hard to assemble] Heartsteel + Tank Engine stack infinite HP, Overlord's Bloodmail converts HP into AD. With Fiora's passive, around 2500 AD a single vital procs 100% max-HP true damage.GragasS+ Tier ComboGragas W gives AP-scaling % damage reduction with a 2.5s invuln after channel. At 2050 AP, 100% reduction. But you have to spend the empowered auto before recasting W, so there's a downtime gap — not perma. Forge: AD (with Adapt) > AP > HP > resists.MelS Tier ComboQ's multi-hits all benefit from Vulnerable's amp — damage is absurd.PykeS Tier ComboPyke passive converts 14 HP into 1 AD; Goliath gives 35% HP and 15% AD, so 8 HP = 1 AD — late, 1000+ AD easy. R scales with both AD and lethality — full-HP squishies are in execute range.Renata GlascS Tier ComboRenata's passive marks enemies; ally damage consumes the mark for % max-HP magic damage. At 600 AP, hits 14% max HP. Stack AP for damage and AS for marking frequency. Damage is attributed to Renata, so magic-pen forge works.RyzeS Tier Combo0.RyzeS Tier ComboSmug emperor — stack Heartsteel to bait enemies.Keep exploring
Mad Scientist Ryze Combo
This S-tier combo pairs Ryze with Mad Scientist in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Ascension combo (go big).