In Mayhem, Sett's W stores up to 35% max HP in grit. W damage scales with grit cap and AD, so stack HP and AD — late, you one-shot. Forge: AD > HP > MS. E pulls both sides together; if both sides have at least one unit (minions count), it stuns — wait for full grit, EW guaranteed.
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About Sett
About Goliath
Goliath
prismatic 55.91% WR
All Sett combos
View all Sett combos → 6 combos
More Goliath Combos
Ryze S Ascension combo. 
Sion S Nobody can resist the joy of getting bigger. 
Xin Zhao S Xin is a physical bruiser, so Master of Duality's AD isn't wasted, plus his E, R, and passive heal scale heavily with AP. Stacking MoD gives huge AP, making heals absurd, and with tank items you sustain forever as long as you don't get one-shot. Stay alive and keep stacking via autos and abilities. 
Shen S Shen's Q empowers his next 3 autos with % max-HP magic damage that scales with AP. Lvl 18 base is 4%; with Q's spirit blade hitting an enemy, it goes to 7% — three autos = 21% max HP. At 400 AP, three autos hit 45% max HP. Spirit-blade pull positioning is huge — hit-vs-miss roughly doubles damage. 
Kled S Slow and Steady converts W's attack-speed bonus into massive AD — pair with lethality for the one-shot route. Kled S Kled's W's 4th hit deals % max-HP physical damage, scaling with HP and AD. Mayhem allows infinite HP/AD stacking, so end-game 4th hit can crush 100%+ max HP. 
Leona S Leona QER are all CC — high frequency Cruelty procs. 
Tahm Kench S Tahm's autos and Q proc bonus damage based on max HP — with hexes you reach absurd resists and HP. He doesn't lack damage; just build 6 tank items. Keep exploring
Sett + Goliath ARAM: Mayhem Combo Guide
This S-tier combo pairs Sett with Goliath in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
In Mayhem, Sett's W stores up to 35% max HP in grit. W damage scales with grit cap and AD, so stack HP and AD — late, you one-shot. Forge: AD > HP > MS. E pulls both sides together; if both sides have at least one unit (minions count), it stuns — wait for full grit, EW guaranteed.