狂気の化学者ランダムミッド: メイヘム combos

Browse 18 ランダムミッド: メイヘム augment combos for 狂気の化学者, with champion and augment synergy picks ranked by tier.

狂気の化学者 augment ランダムミッド: メイヘム tier list All augments

[Hard to scale] Fiddle's Q deals % max-HP magic damage, doubled on feared targets. At 1467 AP, one fear+Q = 100% max HP. Forge: AD (with Adapt) > AP > magic pen. Hide in bush, one Q scares them dead.

フィオラ + クエスト: 覚悟を決めろ S+

[Hard to assemble] Heartsteel + Tank Engine stack infinite HP, Overlord's Bloodmail converts HP into AD. With Fiora's passive, around 2500 AD a single vital procs 100% max-HP true damage.

グラガス + 変力装置 S+

Gragas W gives AP-scaling % damage reduction with a 2.5s invuln after channel. At 2050 AP, 100% reduction. But you have to spend the empowered auto before recasting W, so there's a downtime gap — not perma. Forge: AD (with Adapt) > AP > HP > resists.

メル + 搦め手 S

Q's multi-hits all benefit from Vulnerable's amp — damage is absurd.

パイク + 大巨人 S

Pyke passive converts 14 HP into 1 AD; Goliath gives 35% HP and 15% AD, so 8 HP = 1 AD — late, 1000+ AD easy. R scales with both AD and lethality — full-HP squishies are in execute range.

レナータ・グラスク + クエスト: ウーグレットウィッチキャップ S

Renata's passive marks enemies; ally damage consumes the mark for % max-HP magic damage. At 600 AP, hits 14% max HP. Stack AP for damage and AS for marking frequency. Damage is attributed to Renata, so magic-pen forge works.

ライズ + 大巨人 S

ライズ + 狂気の化学者 S 最強

アセンションコンボ（大きくなろう）。

ライズ + 大巨人 S

Smug emperor — stack Heartsteel to bait enemies.

ライズ + ヴォイドの裂谷 S

Void Rift ascends. Perfect synergy.

セト + 大巨人 S

In Mayhem, Sett's W stores up to 35% max HP in grit. W damage scales with grit cap and AD, so stack HP and AD — late, you one-shot. Forge: AD > HP > MS. E pulls both sides together; if both sides have at least one unit (minions count), it stuns — wait for full grit, EW guaranteed.

シェン + 初志貫徹 S

Shen's Q empowers his next 3 autos with % max-HP magic damage that scales with AP. Lvl 18 base is 4%; with Q's spirit blade hitting an enemy, it goes to 7% — three autos = 21% max HP. At 400 AP, three autos hit 45% max HP. Spirit-blade pull positioning is huge — hit-vs-miss roughly doubles damage.