吶兒+旋風鎚S+Mini Gnar W has 100% AP scaling and 14% max-HP damage. Fan the Hammer applies 5 on-hits per auto + 2 triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, one auto deletes most HP. One auto fills rage bar; mega form is less useful — manage your aggression timing.
汎+旋風鎚S+Fan the Hammer applies 5 on-hits per auto plus the auto itself triggers two triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, a single auto deletes most of an enemy's HP. Vayne is a top focus target — build defense and lifesteal later; if enemy is squishy, single-Q route works fine.
克黎思妲+寶石手套AE has high AP ratios — core idea is using E's burst as your damage. Even on AP, rend stays physical, so build armor pen.
瑟雷西+射手法師AUse Marksmage to convert Thresh's infinite passive AP (via souls) into 75% bonus physical on autos. Combined with E passive's soul-based bonus magic damage and item on-hits, it's a triple-mixed-damage hit — melts squishies and tanks alike. Thresh's passive permanently gives AP and armor, so Marksmage scales endlessly. Stack souls + AS + AP.
汎+蛋白飲AProtein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.