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BrandS+ Tier ComboCentered on Infernal Conduit — burn applies CDR continuously. In 5v5 Mayhem, burning multiple enemies = effectively infinite cast. With Infernal Conduit + sustained-damage items, you spam abilities nonstop.
UdyrS+ Tier ComboUdyr's awakened Q empowered auto deals max-HP physical damage for instant deletes — higher ceiling than AP, but short range hurts. Awakened Q hits 6 lightning bolts dealing max-HP magic damage that bounces between enemies; isolated targets eat the full burst.
Bel'VethS Tier ComboBel'Veth's Q and W are AoE — multi-hits cut multiple CDs, making QWE basically zero-CD. Infinite QW knockup.
BriarS Tier ComboCrit build deals huge damage — lifesteal heals you to full through Grievous Wounds in two bites.BriarS Tier ComboBriar with max crit damage hits hard, which means more lifesteal; stack omnivamp around full-crit goal. Counterintuitive tips: do NOT pick Slow and Steady (Prismatic = Aim); do NOT build boots, Liandry's, or Collector (only build Collector vs full-squishy or full-backline; if there are 2+ bruisers, skip it unless you have Upgrade Collector). Without lifesteal hex, prioritize crit hex — items only give 75% crit cap; otherwise pick Triple-Stack Dragon synergies to amp Hubris. If under crit cap, forge crit. With Mystic Punch, skip Navori; otherwise 99% of matches need it for full uptime W and Q. Master long-range WQ snipes (don't underestimate — range matches J4 EQ).
GarenS Tier ComboCrit + on-hit endless E. Double Tap + Tap Dancer — once crit-capped, E stacks Tap Dancer; faster AS = more spins = infinite E. Add Slow and Steady AS-to-AD, throw in any lifesteal hex, you're invincible.
GravesS Tier ComboGraves's autos on the same target don't reset Don't Blink charging — every auto carries the on-hit; Stormrazor extends range.GravesS Tier ComboConvert Graves's massive AP into bonus physical on-hit via Marksmage. His autos fire 4 pellets, each triggering independently — one auto = +300% AP. Late-game with Ruined King pellets become 6 for 4.5x AP scaling. Only viable when first hex is Marksmage; otherwise pure AD outperforms. Bonus damage is physical, so Black Cleaver is core late.
+Ult stops healing after picking this. Avoid.
- Combo rating · C tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · A
- From the site champion tier list.
- Champion tier context · Patch 26.20
- Updated Oct 12, 2026
About Dr. Mundo
About Vampirism
Vampirism
gold
You can no longer be healed by allies and your health regeneration is set to 0. Gain 30% omnivamp.
View full augment page →All Dr. Mundo combos
View all Dr. Mundo combos →4 combos
More Vampirism Combos
BrandS+ Tier ComboCentered on Infernal Conduit — burn applies CDR continuously. In 5v5 Mayhem, burning multiple enemies = effectively infinite cast. With Infernal Conduit + sustained-damage items, you spam abilities nonstop.UdyrS+ Tier ComboUdyr's awakened Q empowered auto deals max-HP physical damage for instant deletes — higher ceiling than AP, but short range hurts. Awakened Q hits 6 lightning bolts dealing max-HP magic damage that bounces between enemies; isolated targets eat the full burst.Bel'VethS Tier ComboBel'Veth's Q and W are AoE — multi-hits cut multiple CDs, making QWE basically zero-CD. Infinite QW knockup.BriarS Tier ComboCrit build deals huge damage — lifesteal heals you to full through Grievous Wounds in two bites.BriarS Tier ComboBriar with max crit damage hits hard, which means more lifesteal; stack omnivamp around full-crit goal. Counterintuitive tips: do NOT pick Slow and Steady (Prismatic = Aim); do NOT build boots, Liandry's, or Collector (only build Collector vs full-squishy or full-backline; if there are 2+ bruisers, skip it unless you have Upgrade Collector). Without lifesteal hex, prioritize crit hex — items only give 75% crit cap; otherwise pick Triple-Stack Dragon synergies to amp Hubris. If under crit cap, forge crit. With Mystic Punch, skip Navori; otherwise 99% of matches need it for full uptime W and Q. Master long-range WQ snipes (don't underestimate — range matches J4 EQ).GarenS Tier ComboCrit + on-hit endless E. Double Tap + Tap Dancer — once crit-capped, E stacks Tap Dancer; faster AS = more spins = infinite E. Add Slow and Steady AS-to-AD, throw in any lifesteal hex, you're invincible.GravesS Tier ComboGraves's autos on the same target don't reset Don't Blink charging — every auto carries the on-hit; Stormrazor extends range.GravesS Tier ComboConvert Graves's massive AP into bonus physical on-hit via Marksmage. His autos fire 4 pellets, each triggering independently — one auto = +300% AP. Late-game with Ruined King pellets become 6 for 4.5x AP scaling. Only viable when first hex is Marksmage; otherwise pure AD outperforms. Bonus damage is physical, so Black Cleaver is core late.Keep exploring
Vampirism Dr. Mundo Combo
This C-tier combo pairs Dr. Mundo with Vampirism in ARAM: Mayhem. Generally not recommended — there are better options.
Ult stops healing after picking this. Avoid.