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UdyrS+ Tier ComboUdyr's awakened R deals max-HP magic damage — stack AP and melt enemies with % damage. Drop awakened R right in the pile.
BardS Tier ComboCapybara airdrop perfectly times during ult's stasis — pair with Redemption and Killing Time amps for great damage.
CaitlynS Tier ComboCleanup build — one R kill.
IllaoiA Tier ComboAfter pulling the spirit, hitting it makes the original take double damage amp.
+Glass Cannon is core to the suicide Karthus build. Main-E is more reliable AoE than Q, and Liandry's + Liandry's burn benefits from the Glass Cannon amp. Karthus already trades HP to position, so the % HP cost matters little; maximize damage before death.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · A
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Karthus
About Glass Cannon
Glass Cannon
prismatic44.86% WR
You gain a health threshold equal to 70% maximum health which cannot be modified nor exceeded by any means. In return, you deal bonus true damage equal to 25% of your pre-mitigation damage as melee, or 15% as ranged.
View full augment page →All Karthus combos
View all Karthus combos →8 combos
More Glass Cannon Combos
UdyrS+ Tier ComboUdyr's awakened R deals max-HP magic damage — stack AP and melt enemies with % damage. Drop awakened R right in the pile.BardS Tier ComboCapybara airdrop perfectly times during ult's stasis — pair with Redemption and Killing Time amps for great damage.CaitlynS Tier ComboCleanup build — one R kill.IllaoiA Tier ComboAfter pulling the spirit, hitting it makes the original take double damage amp.Keep exploring
Glass Cannon + Clown College Karthus Combo
This S-tier combo pairs Karthus with Glass Cannon in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Glass Cannon is core to the suicide Karthus build. Main-E is more reliable AoE than Q, and Liandry's + Liandry's burn benefits from the Glass Cannon amp. Karthus already trades HP to position, so the % HP cost matters little; maximize damage before death.