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RellS+ Tier ComboCentered on Tank Engine + Cruelty. Rell's hex pool is extra clean, and combining them gives extreme CC + huge sustained damage for 1v5 plays. With both hexes, Rell becomes a different champion.
CassiopeiaS Tier ComboCass W ground triggers Cruelty over a large sustained area — even enemies who walk in late retrigger it. R petrify enables huge burst. W+R combo dumps multiple Cruelty procs for cleanup.
GalioS Tier ComboUse W, E, and R's CC for full damage. With Cruelty, build mage damage amps — Void Rift combo is insane.
HweiS Tier ComboEvery Hwei E procs Cruelty — EE especially pulls enemies into one spot. Since Cruelty is AoE, grouped enemies eat stacked Comet damage. After EE pulls them in, the more bodies, the more terrifying the damage.
LeonaS Tier ComboLeona QER are all CC — high frequency Cruelty procs.
MilioS Tier ComboUse Q for huge damage. Standard AP build, no heavy hex reliance; with Cruelty, build Stormsurge first.
NamiS Tier ComboQ and R both proc Cruelty multiple times with their AoE.
NeekoS Tier ComboUlt lifts enemies up for a guaranteed Cruelty proc.
+Pairs with E for massive AoE CC into double Cruelty proc. Truly disgusting.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · A
- From the site champion tier list.
- Champion tier context · Patch 26.20
- Updated Oct 12, 2026
About Syndra
About Cruelty
Cruelty
prismaticTier B+
Immobilizing or grounding an enemy champion summons a comet above them that lands at their current location after 1 second, dealing 50 to 150 (+ 40% AP) (+ 4% of your maximum health) magic damage to enemies within the area (6 second cooldown per target per cast instance).
View full augment page →All Syndra combos
View all Syndra combos →3 combos
More Cruelty Combos
RellS+ Tier ComboCentered on Tank Engine + Cruelty. Rell's hex pool is extra clean, and combining them gives extreme CC + huge sustained damage for 1v5 plays. With both hexes, Rell becomes a different champion.CassiopeiaS Tier ComboCass W ground triggers Cruelty over a large sustained area — even enemies who walk in late retrigger it. R petrify enables huge burst. W+R combo dumps multiple Cruelty procs for cleanup.GalioS Tier ComboUse W, E, and R's CC for full damage. With Cruelty, build mage damage amps — Void Rift combo is insane.HweiS Tier ComboEvery Hwei E procs Cruelty — EE especially pulls enemies into one spot. Since Cruelty is AoE, grouped enemies eat stacked Comet damage. After EE pulls them in, the more bodies, the more terrifying the damage.LeonaS Tier ComboLeona QER are all CC — high frequency Cruelty procs.MilioS Tier ComboUse Q for huge damage. Standard AP build, no heavy hex reliance; with Cruelty, build Stormsurge first.NamiS Tier ComboQ and R both proc Cruelty multiple times with their AoE.NeekoS Tier ComboUlt lifts enemies up for a guaranteed Cruelty proc.Keep exploring
Cruelty Syndra Combo
This S-tier combo pairs Syndra with Cruelty in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Pairs with E for massive AoE CC into double Cruelty proc. Truly disgusting.