阿卡莉+狂戰士SLich Bane post-ability gives 50% AS, converted by Slow and Steady to AD, then converted to AP via Adapt.
葛雷夫+射手法師SConvert Graves's massive AP into bonus physical on-hit via Marksmage. His autos fire 4 pellets, each triggering independently — one auto = +300% AP. Late-game with Ruined King pellets become 6 for 4.5x AP scaling. Only viable when first hex is Marksmage; otherwise pure AD outperforms. Bonus damage is physical, so Black Cleaver is core late.
凱爾+雙修大師SKayle's ascended passive bonus fire makes autos count as two hits, so Master of Duality stacks both AD and AP at once. W heals scale massively with AP, and Kayle scales into a god — half-tank for survival. Survive long enough to ramp, then take over.
睿娜妲‧格萊斯克+任務:烏莉特的法帽SRenata's passive marks enemies; ally damage consumes the mark for % max-HP magic damage. At 600 AP, hits 14% max HP. Stack AP for damage and AS for marking frequency. Damage is attributed to Renata, so magic-pen forge works.
泰達米爾+雙修大師STrynd's Q has huge AP scaling (1.2x) plus heal scaling; Master of Duality's AP enables full-HP heals. Navori cuts Q CD — extreme survivability. Weave autos and abilities to constantly proc heals and keep MoD stacks up.
沃維克+死亡循環SWarwick's auto and Q heals both proc 5x Circle of Death; Q has 100% AP scaling + % damage. Cast Q at half HP for max heal = max CoD damage.
趙信+雙修大師SXin is a physical bruiser, so Master of Duality's AD isn't wasted, plus his E, R, and passive heal scale heavily with AP. Stacking MoD gives huge AP, making heals absurd, and with tank items you sustain forever as long as you don't get one-shot. Stay alive and keep stacking via autos and abilities.
尤娜拉+雙修大師SRunaan's plus Q stacks Master of Duality quickly; passive deals bonus magic damage with AP scaling on crit, scaling harder every fight.