Vayne ARAM: Mayhem combos

Browse 9 ARAM: Mayhem champion combos for Vayne, with champion and augment synergy picks ranked by tier.

Vayne build ARAM: Mayhem tier list All augments

Fan the Hammer applies 5 on-hits per auto plus the auto itself triggers two triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, a single auto deletes most of an enemy's HP. Vayne is a top focus target — build defense and lifesteal later; if enemy is squishy, single-Q route works fine.

Vayne + Dual Wield S God Tier

Rapid three-ring procs.

Vayne + Fan The Hammer S God Tier

Every bolt triggers W passive and on-hit effects.

Vayne + Twice Thrice S God Tier

Procs stack W passive.

Vayne + Shadow Runner S

Use Tumble's empowered auto, Runaan's, and crit effects to max single-auto damage. Use R+Q stealth to reliably trigger reveals. Bad vs tanky comps — no way to chew through front lines. Q-auto-Q-auto, hitting different targets to maintain Conditioning.

Vayne + Double Tap S

Cruise control. Jeweled Gauntlet lets Double Tap work like Ethereal Weapon. Silver: Typhoon, Escape Plan. Gold: Conditioning, Lightning Strike, Vampirism. Prismatic: Dual Wield, Tap Dancer, Master of Duality.

Vayne + Protein Shake A

Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.

Vayne + Tank It Or Leave It A

Burst build for long-range enemy comps — focus instant high physical damage. Best for poke-vs-poke matchups; pick crit-related hexes.

Vayne + Ethereal Weapon B Tech

Q+E stacks W passive. With Duskblade, a single Q procs the third hit.