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AuroraS+ Tier ComboAurora's passive triple-ring deals % max-HP magic damage — at 800 AP it hits 20%+ max HP. Ethereal Weapon multi-procs it for insane burst that pure tanks can't survive. Forge: AP > magic pen. Always grab Ethereal Weapon, then prioritize CDR and MS hexes.
BlitzcrankS+ Tier ComboBlitz's R passive chains lightning between autos — Ethereal Weapon procs on that lightning, which procs the passive again in an infinite loop. Core is Dusk and Dawn for the extra on-hit (otherwise EW's CD breaks the chain). Must take Twin Flames — its bonus damage spawns firecrackers that proc R passive again, infinite knockup chain. NEVER cast R — once used, the passive ends. Use E off CD; EW procs E knockups; theoretically infinite knockups at 150+ haste.
FioraS+ Tier ComboMystic Punch slashes Q's cooldown, opening up Blade Waltz freely. With Slow and Steady you keep E up full uptime + spam Q, soaking up all that converted AD. New Mystic Punch also reduces R — three R's per fight.
HecarimS+ Tier ComboClassic Ethereal Weapon + Mystic Punch combo — abilities trigger on-hit effects to refresh CDs. Hard to assemble — requires both specific hexes; Mystic Punch alone isn't worth it.
UdyrS+ Tier ComboUdyr's awakened R deals max-HP magic damage — stack AP and melt enemies with % damage. Drop awakened R right in the pile.
VarusS+ Tier ComboVarus W stacks up to 3 layers of passive on enemies for max-HP magic damage — at ~600 AP, 3 stacks = 100% HP magic damage. Need magic pen. Max W, level E and Q evenly with priority on E. Forge: magic pen > AD (w/ Adapt) > AP > MS. Ethereal Weapon + Nashor's lets ability damage proc passive twice. Weave autos: aq, aw, ar, wq. W detonation damage scales with Q charge time (up to +50%). W active adds bonus damage — max damage = R, W, max-charge Q to detonate 3 stacks.
AmumuS Tier ComboEthereal Weapon with W on. Pair with on-hit items and ability haste for maximum effect.AuroraS Tier ComboQ+E landing directly stacks 6 layers, triggering the passive twice.
+Q+E stacks W passive. With Duskblade, a single Q procs the third hit.
- Combo rating · B tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · S
- From the site champion tier list.
- Champion tier context · Patch 26.20
- Updated Oct 12, 2026
About Vayne
About Ethereal Weapon
Ethereal Weapon
goldTier S
Your abilities apply on-hit effects (1 second cooldown per target).
View full augment page →All Vayne combos
View all Vayne combos →8 combos
More Ethereal Weapon Combos
AuroraS+ Tier ComboAurora's passive triple-ring deals % max-HP magic damage — at 800 AP it hits 20%+ max HP. Ethereal Weapon multi-procs it for insane burst that pure tanks can't survive. Forge: AP > magic pen. Always grab Ethereal Weapon, then prioritize CDR and MS hexes.BlitzcrankS+ Tier ComboBlitz's R passive chains lightning between autos — Ethereal Weapon procs on that lightning, which procs the passive again in an infinite loop. Core is Dusk and Dawn for the extra on-hit (otherwise EW's CD breaks the chain). Must take Twin Flames — its bonus damage spawns firecrackers that proc R passive again, infinite knockup chain. NEVER cast R — once used, the passive ends. Use E off CD; EW procs E knockups; theoretically infinite knockups at 150+ haste.FioraS+ Tier ComboMystic Punch slashes Q's cooldown, opening up Blade Waltz freely. With Slow and Steady you keep E up full uptime + spam Q, soaking up all that converted AD. New Mystic Punch also reduces R — three R's per fight.HecarimS+ Tier ComboClassic Ethereal Weapon + Mystic Punch combo — abilities trigger on-hit effects to refresh CDs. Hard to assemble — requires both specific hexes; Mystic Punch alone isn't worth it.UdyrS+ Tier ComboUdyr's awakened R deals max-HP magic damage — stack AP and melt enemies with % damage. Drop awakened R right in the pile.VarusS+ Tier ComboVarus W stacks up to 3 layers of passive on enemies for max-HP magic damage — at ~600 AP, 3 stacks = 100% HP magic damage. Need magic pen. Max W, level E and Q evenly with priority on E. Forge: magic pen > AD (w/ Adapt) > AP > MS. Ethereal Weapon + Nashor's lets ability damage proc passive twice. Weave autos: aq, aw, ar, wq. W detonation damage scales with Q charge time (up to +50%). W active adds bonus damage — max damage = R, W, max-charge Q to detonate 3 stacks.AmumuS Tier ComboEthereal Weapon with W on. Pair with on-hit items and ability haste for maximum effect.AuroraS Tier ComboQ+E landing directly stacks 6 layers, triggering the passive twice.Keep exploring
Ethereal Weapon Vayne Combo
This B-tier combo pairs Vayne with Ethereal Weapon in ARAM: Mayhem. Situationally useful but not always the best pick.
Q+E stacks W passive. With Duskblade, a single Q procs the third hit.