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Karthus+Devil on Your Shoulder

Karthus + Devil on Your Shoulder

Combo rating · S tier
Community upvotes
Karthus ARAM Mayhem build →

Max E, sub W — E burn drops fragments wildly; chase fragments, find enemies dead and you're at full HP.

Combo rating · S tier
Editorial assessment, not a win-rate metric.
Guide provenance
ARAM Mayhem editorial
Combo patch
Not recorded
Guide freshness
No update date recorded
Champion tier · A
From the site champion tier list.
Champion tier context · Patch 26.19
Updated Oct 6, 2026
About Karthus
Karthus
Karthus
Champion tier · AMage

the Deathsinger

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About Devil on Your Shoulder
Forge a pact with Teemo, who drains 0.5% of your current health every second, increased to 5% if there are enemy champions within 1000 units. In return, you deal 15% bonus true damage and your basic attacks and abilities summon a Life Remnant nearby for 5 seconds (0.75-second spawn cooldown). You can absorb a Life Remnant by moving over it, healing you for 50 to 150 (+ 50% bonus AD) (+ 25% AP) and granting you 15% bonus movement speed.

Scoring a champion takedown amplifies this augment for 8 seconds, doubling the bonus true damage to 30%, the healing to 100 to 300 (+ 100% bonus AD) (+ 50% AP), and the bonus movement speed to 30%.
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All Karthus combos

View all Karthus combos →
8 combos

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Devil on Your Shoulder Karthus Combo

This S-tier combo pairs Karthus with Devil on Your Shoulder in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.

Max E, sub W — E burn drops fragments wildly; chase fragments, find enemies dead and you're at full HP.