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GnarS+ Tier ComboMini Gnar W has 100% AP scaling and 14% max-HP damage. Fan the Hammer applies 5 on-hits per auto + 2 triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, one auto deletes most HP. One auto fills rage bar; mega form is less useful — manage your aggression timing.VayneS+ Tier ComboFan the Hammer applies 5 on-hits per auto plus the auto itself triggers two triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, a single auto deletes most of an enemy's HP. Vayne is a top focus target — build defense and lifesteal later; if enemy is squishy, single-Q route works fine.
JaxS Tier ComboTanky and high damage.
Master YiS Tier ComboBurst build.Master YiS Tier ComboOn-hit DPS — with Master Yi's E, you cut through anything.
KalistaA Tier ComboE has high AP ratios — core idea is using E's burst as your damage. Even on AP, rend stays physical, so build armor pen.
ThreshA Tier ComboUse Marksmage to convert Thresh's infinite passive AP (via souls) into 75% bonus physical on autos. Combined with E passive's soul-based bonus magic damage and item on-hits, it's a triple-mixed-damage hit — melts squishies and tanks alike. Thresh's passive permanently gives AP and armor, so Marksmage scales endlessly. Stack souls + AS + AP.VayneA Tier ComboProtein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.
+Procs stack W passive.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · S
- From the site champion tier list.
- Champion tier context · Patch 26.20
- Updated Oct 12, 2026
About Vayne
About Twice Thrice
Twice Thrice
gold
Basic attacks generate a stack, up to 2 times. At 2 stacks, your next basic attack consumes all stacks to apply on-hit effects again at 150% effectiveness.
View full augment page →All Vayne combos
View all Vayne combos →8 combos
More Twice Thrice Combos
GnarS+ Tier ComboMini Gnar W has 100% AP scaling and 14% max-HP damage. Fan the Hammer applies 5 on-hits per auto + 2 triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, one auto deletes most HP. One auto fills rage bar; mega form is less useful — manage your aggression timing.VayneS+ Tier ComboFan the Hammer applies 5 on-hits per auto plus the auto itself triggers two triple-ring procs. With Dual Wield + Tap Dancer + Runaan's, a single auto deletes most of an enemy's HP. Vayne is a top focus target — build defense and lifesteal later; if enemy is squishy, single-Q route works fine.JaxS Tier ComboTanky and high damage.Master YiS Tier ComboBurst build.Master YiS Tier ComboOn-hit DPS — with Master Yi's E, you cut through anything.KalistaA Tier ComboE has high AP ratios — core idea is using E's burst as your damage. Even on AP, rend stays physical, so build armor pen.ThreshA Tier ComboUse Marksmage to convert Thresh's infinite passive AP (via souls) into 75% bonus physical on autos. Combined with E passive's soul-based bonus magic damage and item on-hits, it's a triple-mixed-damage hit — melts squishies and tanks alike. Thresh's passive permanently gives AP and armor, so Marksmage scales endlessly. Stack souls + AS + AP.VayneA Tier ComboProtein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.Keep exploring
Twice Thrice Vayne Combo
This S-tier combo pairs Vayne with Twice Thrice in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
Procs stack W passive.