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Vayne + Protein Shake
A Tier Combo
Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.
Submitted by ARAMMayhem.com
About Vayne
About Protein Shake
Protein Shake
prismatic 47.71% WR
All Vayne combos
View all Vayne combos → 8 combos
More Protein Shake Combos
Mordekaiser S W heals based on shield amount, so Protein Shake applies twice. Pair with Circle of Death for one-shots. 
Katarina S Protein Shake plus Statikk Shiv gives huge attack speed; Slow and Steady converts it into AD. Katarina's ult attack-speed isn't affected, and she still benefits from the converted AD. 
Soraka S Support uses Moonstone + Protein Shake multiplicatively for 3.5x healing. Even a squishy enchanter outputs absurd heals when stacked with double-resist items like Jaksho. 
Xin Zhao S Xin is a physical bruiser, so Master of Duality's AD isn't wasted, plus his E, R, and passive heal scale heavily with AP. Stacking MoD gives huge AP, making heals absurd, and with tank items you sustain forever as long as you don't get one-shot. Stay alive and keep stacking via autos and abilities. 
Maokai S Q grants a shield stack per hit — multi-target Q = huge shield. Maokai S Protein Shake gives huge sustain — combined with Maokai's % HP regen passive, you never die. 
Aatrox S With ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely. 
Nautilus S Protein Shake makes Nautilus's W shield enormous — extremely tanky, even better with Heartsteel. Keep exploring
Vayne + Protein Shake ARAM: Mayhem Combo Guide
This A-tier combo pairs Vayne with Protein Shake in ARAM: Mayhem. A solid choice that works well in most games.
Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.