← Back to Combos
+
MordekaiserS+ Tier ComboCircle of Death deals 70% of heal as damage. Protein Shake amps shield/heal — Morde's W shield's heal-when-broken scales, dealing damage. Late, one W full-heal deletes squishies; W grants gray HP based on damage dealt, so with Executioner you can spam W forever. Never build Rift Maker or any omnivamp item — they override CoD damage. CoD deals magic damage — build magic pen. Enemy Serpent's Fang chunks your shield and damage.
AatroxS Tier ComboWith ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely.
AlistarS Tier ComboAlistar's Q is group CC and procs Colossus multiple times for an instantly huge shield — high haste means frequent Q, basically unkillable. Build full tank; Colossus has 5s CD, so dump full combo each fight, then Q to proc Colossus — bigger shield per enemy hit.
GarenS Tier ComboProtein Shake + Statikk Shiv.GarenS Tier ComboInvincible. Charge in invuln.GarenS Tier ComboProtein Shake + Slow and Steady + Statikk Shiv — left foot on right foot. Dual resist → shield, shield → AS, AS → AD. Cruise to victory.
KatarinaS Tier ComboProtein Shake plus Statikk Shiv gives huge attack speed; Slow and Steady converts it into AD. Katarina's ult attack-speed isn't affected, and she still benefits from the converted AD.KatarinaS Tier ComboProtein Shake + Statikk Shiv + Slow and Steady = high-burst, tanky god. Pure luck — if you roll it, you win.
+Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.
- Combo rating · A tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · S
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Vayne
About Protein Shake
Protein Shake
prismatic50.94% WR
Gain 25% (+ 35% per 100 bonus armor) (+ 35% per 100 bonus magic resistance) heal and shield power.
View full augment page →All Vayne combos
View all Vayne combos →8 combos
More Protein Shake Combos
MordekaiserS+ Tier ComboCircle of Death deals 70% of heal as damage. Protein Shake amps shield/heal — Morde's W shield's heal-when-broken scales, dealing damage. Late, one W full-heal deletes squishies; W grants gray HP based on damage dealt, so with Executioner you can spam W forever. Never build Rift Maker or any omnivamp item — they override CoD damage. CoD deals magic damage — build magic pen. Enemy Serpent's Fang chunks your shield and damage.AatroxS Tier ComboWith ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely.AlistarS Tier ComboAlistar's Q is group CC and procs Colossus multiple times for an instantly huge shield — high haste means frequent Q, basically unkillable. Build full tank; Colossus has 5s CD, so dump full combo each fight, then Q to proc Colossus — bigger shield per enemy hit.GarenS Tier ComboProtein Shake + Statikk Shiv.GarenS Tier ComboInvincible. Charge in invuln.GarenS Tier ComboProtein Shake + Slow and Steady + Statikk Shiv — left foot on right foot. Dual resist → shield, shield → AS, AS → AD. Cruise to victory.KatarinaS Tier ComboProtein Shake plus Statikk Shiv gives huge attack speed; Slow and Steady converts it into AD. Katarina's ult attack-speed isn't affected, and she still benefits from the converted AD.KatarinaS Tier ComboProtein Shake + Statikk Shiv + Slow and Steady = high-burst, tanky god. Pure luck — if you roll it, you win.Keep exploring
Protein Shake + Twice Thrice Vayne Combo
This A-tier combo pairs Vayne with Protein Shake in ARAM: Mayhem. A solid choice that works well in most games.
Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.