Protein Shake

With ~250 dual resists from half-tank items, Protein Shake + Iceborn Gauntlet multiplies heals/shields up to 3.5x — Sundered Sky and Death's Dance benefit hugely.

Alistar's Q is group CC and procs Colossus multiple times for an instantly huge shield — high haste means frequent Q, basically unkillable. Build full tank; Colossus has 5s CD, so dump full combo each fight, then Q to proc Colossus — bigger shield per enemy hit.

Protein Shake + Statikk Shiv.

Invincible. Charge in invuln.

Protein Shake + Slow and Steady + Statikk Shiv — left foot on right foot. Dual resist → shield, shield → AS, AS → AD. Cruise to victory.

Protein Shake plus Statikk Shiv gives huge attack speed; Slow and Steady converts it into AD. Katarina's ult attack-speed isn't affected, and she still benefits from the converted AD.

Protein Shake + Statikk Shiv + Slow and Steady = high-burst, tanky god. Pure luck — if you roll it, you win.

Late-game 5000-HP shield — insane. Don't cast R — it reduces resists and shrinks the shield.

Q grants a shield stack per hit — multi-target Q = huge shield.

Maokai's QWR all proc Colossus's Courage shield; Protein Shake amps shield and passive heal — just stick W on enemies and chain QWR.

Protein Shake gives huge sustain — combined with Maokai's % HP regen passive, you never die.

W heals based on shield amount, so Protein Shake applies twice. Pair with Circle of Death for one-shots.

Chili Oil stand-fight — pick Chili Oil, dive in, fight via passive.

Protein Shake makes Nautilus's W shield enormous — extremely tanky, even better with Heartsteel.

Protein Shake Rammus — full tank, AS easily hits 5.0. Protein Shake fits perfectly with W.

AS-enchanter Senna — tanky and durable.

Heal then poison-shockwave for the win. Stack heal first; with Protein Shake, swap to tanky.

Support uses Moonstone + Protein Shake multiplicatively for 3.5x healing. Even a squishy enchanter outputs absurd heals when stacked with double-resist items like Jaksho.

Xin is a physical bruiser, so Master of Duality's AD isn't wasted, plus his E, R, and passive heal scale heavily with AP. Stacking MoD gives huge AP, making heals absurd, and with tank items you sustain forever as long as you don't get one-shot. Stay alive and keep stacking via autos and abilities.

Doubles crit chance via passive — Ruined King alone takes you near max crit. Yasuo's high-frequency Q and E refresh shields constantly, while Death's Dance bleed makes him both tanky and bursty.

Use Circle of Death to convert massive heals into magic damage — pair with Zac's huge HP and % HP regen to play laser tower. Higher HP = bigger heal = bigger CoD damage; build HP and healing-boost hexes.

Use Protein Shake to convert resists into heal amp — at 350 dual resists with Iceborn Gauntlet, heals multiply by 4.6x, ignoring Grievous Wounds.

Protein Shake + Statikk Shiv — tanky, heal, and shield all in one.

Protein Shake + Statikk Shiv gives high AS, paired with Conditioning for huge ally heals; meanwhile use W passive for damage.