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Miss FortuneS+ Tier ComboW and E have very short CDs and Archmage chains them — W reduces E, E reduces W — full-screen bullet hell. Needs 200+ haste; pair with haste hexes.
RyzeS+ Tier ComboUse Ryze's passive AP-mana cross-scaling with specific items and hexes to loop mana/HP/AD conversions for infinite stat growth. Must take Adapt + Mind to Matter; Ryze lacks mobility, so don't sell boots without MS hexes; vs tanks build Void Staff; multiple Tear items stack slowly — pace your farm.
ZileanS+ Tier ComboWith Archmage's bond, Q reduces W's CD while W's mechanic reduces Q. At 110 ability haste, infinite QW. Just alternate QW endlessly and chain-control to death.
AlistarS Tier ComboArchmage + ~190 haste enables infinite WQ knockup. Don't cast E — just WQ on loop.
BlitzcrankS Tier ComboCombine Archmage with ~300 ability haste for infinite R.
HecarimS Tier ComboPrismatic priority Dropkick, gold priority Overflow, silver priority Mind to Matter — assemble Archmage. Forge priority omnivamp + CDR. Easy to play; watch your mana late.
KassadinS Tier ComboKassadin E has a 90% slow — during the slow, he opens up 400+ MS gaps, locking in Don't Blink's 40% damage amp on the rest of his combo. Lead with E slow for max amp.KassadinS Tier ComboKassadin's E and R are AoE — multi-hits proc multiple Void Rifts.
+W reduces R's CD via Archmage's CDR refund. After casting R, spam W and Q to slash R's CD for full-map ults. R then W, spam Q during both cooldowns, recast W, repeat — about 16s per ult.
- Combo rating · S tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · A
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Karthus
About Mind to Matter
All Karthus combos
View all Karthus combos →8 combos
More Mind to Matter Combos
Miss FortuneS+ Tier ComboW and E have very short CDs and Archmage chains them — W reduces E, E reduces W — full-screen bullet hell. Needs 200+ haste; pair with haste hexes.RyzeS+ Tier ComboUse Ryze's passive AP-mana cross-scaling with specific items and hexes to loop mana/HP/AD conversions for infinite stat growth. Must take Adapt + Mind to Matter; Ryze lacks mobility, so don't sell boots without MS hexes; vs tanks build Void Staff; multiple Tear items stack slowly — pace your farm.ZileanS+ Tier ComboWith Archmage's bond, Q reduces W's CD while W's mechanic reduces Q. At 110 ability haste, infinite QW. Just alternate QW endlessly and chain-control to death.AlistarS Tier ComboArchmage + ~190 haste enables infinite WQ knockup. Don't cast E — just WQ on loop.BlitzcrankS Tier ComboCombine Archmage with ~300 ability haste for infinite R.HecarimS Tier ComboPrismatic priority Dropkick, gold priority Overflow, silver priority Mind to Matter — assemble Archmage. Forge priority omnivamp + CDR. Easy to play; watch your mana late.KassadinS Tier ComboKassadin E has a 90% slow — during the slow, he opens up 400+ MS gaps, locking in Don't Blink's 40% damage amp on the rest of his combo. Lead with E slow for max amp.KassadinS Tier ComboKassadin's E and R are AoE — multi-hits proc multiple Void Rifts.Keep exploring
Mind to Matter + Ocean Soul Karthus Combo
This S-tier combo pairs Karthus with Mind to Matter in ARAM: Mayhem. This is one of the strongest combos available — pick it whenever you can.
W reduces R's CD via Archmage's CDR refund. After casting R, spam W and Q to slash R's CD for full-map ults. R then W, spam Q during both cooldowns, recast W, repeat — about 16s per ult.