← Back to Combos
+
YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.
TryndamereS Tier ComboBest Scope ADC.
XayahS Tier ComboForge: omnivamp > AS > armor pen > AD > MS.YasuoS Tier ComboDoubles crit chance via passive — Ruined King alone takes you near max crit. Yasuo's high-frequency Q and E refresh shields constantly, while Death's Dance bleed makes him both tanky and bursty.
+Burst build for long-range enemy comps — focus instant high physical damage. Best for poke-vs-poke matchups; pick crit-related hexes.
- Combo rating · A tier
- Editorial assessment, not a win-rate metric.
- Guide provenance
- ARAM Mayhem editorial
- Combo patch
- Not recorded
- Guide freshness
- No update date recorded
- Champion tier · S
- From the site champion tier list.
- Champion tier context · Patch 26.19
- Updated Oct 6, 2026
About Vayne
About Tank It Or Leave It
Tank It Or Leave It
silver54.95% WR
Gain Critical Defend Chance equal to 100% critical strike chance, up to 50%. Additionally, gain 25% critical strike chance.
Critical Defend Chance: Grants you a chance to reduce an instance of damage taken by 20%.
View full augment page →Critical Defend Chance: Grants you a chance to reduce an instance of damage taken by 20%.
All Vayne combos
View all Vayne combos →8 combos
More Tank It Or Leave It Combos
YasuoS+ Tier ComboMystic Punch autos reduce all CDs by 1.25s; Yasuo's Q counts as an auto, so at 1.33s Q CD, you get infinite Q. Ruined King keeps shields up.TryndamereS Tier ComboBest Scope ADC.XayahS Tier ComboForge: omnivamp > AS > armor pen > AD > MS.YasuoS Tier ComboDoubles crit chance via passive — Ruined King alone takes you near max crit. Yasuo's high-frequency Q and E refresh shields constantly, while Death's Dance bleed makes him both tanky and bursty.Keep exploring
Tank It Or Leave It + Upgrade Infinity Edge Vayne Combo
This A-tier combo pairs Vayne with Tank It Or Leave It in ARAM: Mayhem. A solid choice that works well in most games.
Burst build for long-range enemy comps — focus instant high physical damage. Best for poke-vs-poke matchups; pick crit-related hexes.